Table 4

Comparison of CLint in slices and isolated hepatocytes and Vapp observed in slices and predicted from isolated hepatocytes

CompoundCLint4-aVapp
SlicesHepatocytesSlice:Hepatocyte RatioSlicesPredicted from Hepatocytes4-bSlice:Hepatocyte Ratio
Caffeine0.61.40.4326.5261.0
Tolbutamide0.41.60.2527.4251.1
Phenytoin6.5370.18166.82400.69
Diazepam8.6820.10180.75270.34
Ondansetron5.01120.05195.24700.42

  • ↵4-a Data from ref. 5.

  • ↵4-b Using eq. 5 and Kp data from ref. 20.