Table 1

Tissue-to-plasma ratios of AZT at different times after dosing

	Bone Marrow^1-a	Lymph Nodes^1-b	Spleen^1-b	Thymus^1-b	Brain^1-b	Liver^1-b	Kidneys^1-b	Lung^1-b	Heart^1-b	Muscle^1-b
Control
30 min	0.698	0.241	0.745	0.434	0.062	0.556	2.616	0.559	0.588	0.686
	±0.010	±0.010	±0.189	±0.084	±0.004	±0.127	±0.384	±0.056	±0.065	±0.025
60 min	0.850	0.379^1-c	0.627	0.493	0.096^1-c	0.568	2.749	0.633	0.659	0.769
	±0.265	±0.077	±0.080	±0.164	±0.007	±0.088	±0.382	±0.040	±0.031	±0.115
90 min	1.44^1-c ^, ^1-d	0.418^1-c	0.627	0.405	0.167^1-c ^, ^1-d	0.518	2.853	0.655	0.686	0.876
	±0.161	±0.057	±0.058	±0.040	±0.017	±0.142	±0.454	±0.062	±0.048	±0.159

Infected
30 min	0.766	0.759^1-e	0.755	0.489	0.071	0.628	1.642^1-e	0.606	0.648	0.693
	±0.298	±0.145	±0.114	±0.017	±0.012	±0.148	±0.845	±0.074	±0.095	±0.142
90 min	2.61	0.738^1-e	0.677	0.634	0.097^1-e	0.642	1.894^1-e	1.207	0.701	1.274
	±1.71	±0.018	±0.049	±0.171	±0.023	±0.087	±0.062	±0.668	±0.023	±0.502

Ratios of tissue-to-plasma levels of AZT of control and LP-BM5 MuLV-inoculated animals at different times after subcutaneous administration of a 25 mg/kg dose of AZT. Data are mean ±1 SD of four mice.

↵1-a Tissue-to-plasma ratios are presented as dpm/10¹⁰ cells over dpm/ml plasma.
↵1-b Tissue-to-plasma ratios are presented as dpm/g tissue over dpm/ml plasma.
↵1-c Significantly different from the corresponding values in the same study group at 30 min after dosing,p < 0.05.
↵1-d Significantly different from the corresponding values in the same study group at 60 min after dosing,p < 0.05.
↵1-e Significantly different from that determined at the respective times after dosing of the control animals,p < 0.05.