Table 2

Tissue-to-plasma ratios of AZT-MP at 90 min after dosing

Bone Marrow2-aLymph Nodes2-bSpleen2-bThymus2-bBrain2-bLiver2-bKidneys2-bLung2-bHeart2-bMuscle2-b
Control6.312-c 0.4902.542-c  0.4510.1481.3872-c   4.322-c 0.8131.130.781
±2.55±0.124±0.907±0.345±0.065±0.107±0.449±0.036±0.231±0.275
Infected5.492-c 1.162-c , 2-d2.082-c  1.112-c , 2-d0.0572-d1.0742-c  2.232-c , 2-d0.8920.6002-d0.4782-c
±2.41±0.314±0.035±0.274±0.019±0.119±0.162±0.048±0.029±0.096

Ratios of tissue-to-plasma levels of AZT-MP of control and LP-BM5 MuLV-inoculated animals at 90 min after subcutaneous administration of a 25 mg/kg dose of AZT. Data are mean ±1 SD of four mice.

  • 2-a Tissue-to-plasma ratios are presented as dpm/1010 cells over dpm/ml plasma.

  • 2-b Tissue-to-plasma ratios are presented as dpm/g tissue over dpm/ml plasma.

  • 2-c Significantly different from the respective tissue-to-plasma ratios of AZT at 90 min after dosing (AZT data are shown in table 1), p < 0.05.

  • 2-d Significantly different from the respective values of the control animals, p < 0.05.