Amount of total TCEOH and TCA found in urine over a period of 0 to 48 hr after intravenous doses of TCEOH (5 and 100 mg/kg) in male F-344 rats (N = 4), with intact enterohepatic recirculation (EHC) and without it (as indicated)
| Metabolite | Dose | Without EHC | With EHC | ||
|---|---|---|---|---|---|
| Amount | % Dose | Amount | % Dose | ||
| mg/kg | mg | mg | |||
| TCEOH | 5 | 0.5 ± 0.2 | 35.5 | — | — |
| TCA | 5 | 0.01 ± 0.002 | 0.7 | — | — |
| TCEOH | 20 | 3.1 ± 0.3 | 54.3 | — | — |
| TCA | 20 | 0.03 ± 0.003 | 0.5 | — | — |
| TCEOH | 100 | 8.1 ± 0.3 | 28.3 | 7.9 ± 0.6 | 27.4 |
| TCA | 100 | 0.09 ± 0.02 | 0.3 | 0.46 ± 0.06 | 1.6 |
% of initial TCEOH dose recovered in urine as total TCEOH or TCA over the 0- to 48-hr period.