Phenolic phase II conjugates of rhein and its phase I metabolites
| Sample | G I | G II | Glu I | Glu II | Glu III | Di-Glu | S I | S II | OH-Glu I/II | 2OH Glu I/II | CH Glu |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rabbit (urine) | +++ | +++ | + | + | +/+ | +/+ | + | ||||
| Rat (urine) | +++ | + | ++ | +++ | + | +/+ | +/+ | ||||
| Dog (urine) | +++ | +++ | +++ | +++ | + | + | +/+ | +/+ | |||
| Humans (urine) | + | +++ | + | +++ | ++ | +++ | ++ | +/+ | |||
| Rabbit (microsomes) | + | +++ | + | +/+ | |||||||
| Rat (microsomes) | ++ | ++ | +++ | + |
Rhein: G I-II, glucosides; Glu I-III, glucuronides; DiGlu, bisether-ester-glucuronide; S I-II, sulfates; Phase-I-metabolites of rhein: OH-Glu I-II, glucuronides of monohydroxylated rhein; 2OH-Glu I-II, glucuronides of the bishydroxylated rhein; CHGlu, glucuronide of the quinoid product.