Comparison of the uptake clearances of [14C]octreotide determined in vivo and in vitro
| In Vivo | Isolated Cells | Primary Cultured Cells | |||
|---|---|---|---|---|---|
| μl/min/mg protein | — | 2.573-a | 2.463-b | ||
| ml/min/g liver | 0.203-c | 0.233-d | 0.263-e | 0.223-d | 0.263-e |
↵3-a Observed value with isolated hepatocytes (= Vmax/KM +Pdiff).
↵3-b Observed value with primary cultured hepatocytes (= Vmax/KM +Pdiff).
↵3-c Observed value obtained from integration plot method (fig. 3).
↵3-d Calculated based on the sinusoidal perfusion model (eq. 8).
↵3-e Calculated based on the venous equilibrium model (eq. 9).