Table 2

AZT infusion pharmacokinetic parameters

Animal ID No.	Weight	Infusion Rate^2-a	IV Bolus^2-a	C_pssm	CL	Vd_ss	Concentration Ratios
Animal ID No.	Weight	Infusion Rate^2-a	IV Bolus^2-a	C_pssm	CL	Vd_ss	C_pssf/C_pssm	C_pssf/AF_ss
	kg	μg/min/kg	mg/kg	μg/ml	ml/min/mg	liters/kg
R4707	9.1	44.80	1.466	1.529	29.29	0.96	0.867	1.048
E480	8.9	30.42	1.281	1.296	23.47	0.99	0.634	1.035
R21	12.0	50.04	2.256	2.151	23.26	1.10	0.883	1.446
R4912	8.9	41.02	1.476	1.741	23.56	0.85	0.995	1.220

Mean				1.68	24.90	0.97	0.845	1.187
± SD				±0.36	±2.93	±0.10	±0.152	±0.192

Maternal plasma, fetal plasma, and amniotic fluid were collected and analyzed using reversed-phase HPLC. C_pssm, maternal steady-state plasma concentration;C_pssf/C_pssm, fetal-to-maternal AZT plasma ratios at steady-state;C_pssf/AF_ss, fetal plasma-to-amniotic fluid ratios at steady-state.

↵2-a Based on the calculations using data from table 1 and 2 μg/ml as the target steady-state plasma concentration.