Volume of distribution and elimination parameter estimates for cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide in patients receiving cyclophosphamide at 4 g/m2/90 min
| Patient | V = Vmet (L) | Vmax (μM/min) | Km (μM) | Clnr (ml/min) | Clr (ml/min) | Clmet/Fmet (ml/min) |
|---|---|---|---|---|---|---|
| 1 | 45 | 64 | 25 | 3632 | ||
| 2 | 37 | 84 | 19 | 3331 | ||
| 3 | 63 | 0.27 | 70 | 32 | 3689 | |
| 4 | 59 | 76 | 57 | 4115 | ||
| 5 | 47 | 0.70 | 192 | 15 | 3142 | |
| 6 | 43 | 0.63 | 167 | 22 | 1987 | |
| 7 | 48 | 0.56 | 154 | 25 | 1920 | |
| 8 | 36 | 54 | 27 | 1742 | ||
| 9 | 42 | 0.67 | 205 | 39 | 2408 | |
| 10 | 32 | 58 | 30 | 2411 | ||
| 11 | 34 | 1.53 | 450 | 17 | 3158 | |
| 12 | 49 | 1.13 | 494 | 38 | 4245 | |
| Mean | 45 | 0.78 | 247 | 67 | 29 | 2982 |
| Median | 44 | 0.67 | 192 | 64 | 26 | 3150 |
| SD | 9 | 0.38 | 148 | 11 | 11 | 831 |