Table 2

Correlation of PCP metabolite formation with CYP isoform activities in human liver microsomal samples 2-a , 2-b

PCP MetaboliteCYP isoform that Correlates with PCP Metabolite FormationCorrelation Coefficient (r)p value
c-PPCCYP3A0.760.011
t-PPCCYP3A0.700.025
PCHPCYP1A0.740.012
Unknown MetaboliteCYP2A0.660.039
Irreversibly bound PCP MetaboliteCYP3A0.680.029

  • ↵2-a N = 10 per group.

  • ↵2-b CYP activities that did not show a significant correlation were CYP2C, CYP2D, CYP2E, CYP4A, and lauric acid 11-hydroxylation.