Concentration (μg Equivalent of Toborinone/g) or % of Radioactivity in Sample | ||||||||
---|---|---|---|---|---|---|---|---|
Plasma | Liver | Kidney | Heart | |||||
10 Min | 1 Hr | 10 Min | 1 Hr | 10 Min | 1 Hr | 10 Min | 1 Hr | |
Total 14C | 11.677 | 3.477 | 29.542 | 10.608 | 113.688 | 10.557 | 14.152 | 3.058 |
(μg eq/g tissue)3-a | ±0.907 | ±0.206 | ±3.628 | ±0.229 | ±11.048 | ±1.028 | ±1.491 | ±0.090 |
M-1 | 7.61 | 7.05 | 18.08 | 12.39 | 1.55 | 4.69 | 1.26 | 1.65 |
M-2 | 3.10 | 11.94 | 12.11 | 16.33 | 1.10 | 4.94 | 0.40 | 2.53 |
M-3 | 1.26 | 2.33 | 2.04 | 1.72 | 0.58 | 5.46 | 1.27 | 2.97 |
M-4 | 0.09 | 0.05 | 0.47 | ND | ND | 0.18 | ND | ND |
M-5 | 0.04 | 0.08 | 0.59 | 0.13 | ND | 0.10 | ND | ND |
M-6 | 1.48 | 6.46 | 1.74 | 1.49 | 0.45 | 1.46 | 0.21 | 1.20 |
M-7 | 0.51 | 0.48 | 6.88 | 6.36 | 3.01 | 4.57 | 0.08 | 0.15 |
M-8 | 0.09 | 0.39 | 0.14 | 0.21 | ND | 0.22 | ND | ND |
M-9 | 0.72 | 0.45 | 0.60 | 0.42 | 1.08 | 2.46 | 0.07 | ND |
Toborinone | 80.87 | 67.05 | 49.00 | 52.89 | 86.00 | 70.08 | 84.16 | 78.29 |
Total14C | 95.77% | 96.28% | 91.65% | 91.94% | 93.77% | 94.16% | 87.45% | 86.79% |
Values represent the mean of data from four animals. ND, not detected.
↵3-a Values represent the mean ± SE of data from four animals.