Yeast Extract | Trypticase Soy | Phosphate Buffer | Czapec Dox | Casamino Acids | Malt Extract | Peptone | Sabouraud Dextrose | |
---|---|---|---|---|---|---|---|---|
Minimum concentration of mexiletine remaining (μg/ml) | ||||||||
S-(+)-mexiletine | 14.9 | 13.4 | 26.5 | 43.6 | 44.6 | 45.2 | 22.3 | 16.2 |
R-(−)-mexiletine | 7.6 | 10.4 | 23.6 | 36.2 | 29.8 | 46.0 | 16.1 | 9.4 |
Ratio ofS-(+)-mex/R-(−)-mex | 1.97 | 1.29 | 1.12 | 1.21 | 1.50 | 1.00 | 1.39 | 1.71 |
Maximum concentration of HMM produced (μg/ml) | ||||||||
S-HMM | 17.8 | 12.7 | 8.1 | 10.9 | 9.5 | 4.9 | 12.05 | 11.9 |
R-HMM | 12.3 | 11.8 | 7.7 | 10.3 | 7.7 | 5.2 | 9.85 | 11.8 |
Ratio ofS-(+)-mex/R-(−)-mex | 1.44 | 1.10 | 1.05 | 1.06 | 1.23 | 0.93 | 1.22 | 1.00 |
Time required to reach optimal concentration (hr) | 83 | 21 | 45 | 118 | 200 | 105 | 200 | 76 |
Maximum concentration of PHM produced (μg/ml) | ||||||||
S-PHM | 24.1 | 15.3 | 10.2 | 11.9 | 14.3 | 6.9 | 16.4 | 12.5 |
R-PHM | 40.5 | 32.2 | 20.4 | 25.7 | 34.0 | 10.5 | 39.2 | 26.6 |
Ratio ofS-(+)-mex/R-(−)-mex | 0.61 | 0.48 | 0.50 | 0.46 | 0.42 | 0.65 | 0.42 | 0.47 |
Time required to reach optimal concentration (hr) | 83 | 21 | 76 | 118 | 200 | 105 | 200 | 76 |
Summary of data obtained from the eight media preparations devised to test rac-mexiletine metabolism by C. echinulata.
mex, mexiletine.