Table 1

Excretion of radioactivity after doses of [14C]LY231514 in mouse and dog

Fraction/Time Interval (hr)MouseDog
Urine
 0–2434  ± 265  ± 18
 24–480.81  ± 0.552.0  ± 1.0
 48–720.32  ± 0.150.59  ± 0.16
 72–960.21  ± 0.080.44  ± 0.67
 96–120ND1-a 0.32  ± 0.21
 120–144ND0.23  ± 0.20
144–168ND0.11  ± 0.05
 Total Urine35  ± 269  ± 18
Feces
 0–2455  ± 1422  ± 4
 24–481.6  ± 0.83.6  ± 3.4
 48–720.50  ± 0.121.5  ± 1.7
 72–960.45  ± 0.270.82  ± 0.58
 96–120ND0.36  ± 0.22
 120–144ND1.5  ± 2.2
 144–168ND0.44  ± 0.27
 Total Feces57  ± 1431  ± 7
Carcass0.15  ± 0.02ND
Total92  ± 1499  ± 13

An intravenous dose of 20 mg/kg and 7.5 mg/kg (50 μCi/kg in mice, 5 μCi/kg in dog) was given to four groups of two male CD-1 mice and four female dogs, respectively. Data represent the percentage of administered radiocarbon recovered at each time interval ± SD.

  • ↵1-a ND, not determined.