Selected pharmacokinetic parameters for dog and mouse dosed intravenously with LY231514 Na2
| Species | Mouse | Dog | Dog | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sex | M | M | M | M | F | M | F | ||
| Dose (mg/kg) | 20 | 20 | 200 | 7.5 | 7.5 | 100 | 100 | ||
| Route | IV | IP | IP | IV | IV | IV | IV | ||
| t max(hr) | 0.083 | 0.25 | 0.25 | 0.083 | 0.083 | 0.083 | 0.083 | ||
| C max(μg/ml) | 41 | 33 | 196 | 38 ± 2 | 49 ± 9 | 530 ± 14 | 459 ± 36 | ||
| t 1/2, hr (interval, hr/hr), | 7 (1–48) | 7.8 (2–48) | 10 (6–48) | 2.8 (1–24) | 1.8 (1–12) | 2.3 (1–24) | 2.2 (1–24) | ||
| AUC (μg/hr/ml) | 31 | 44 | 220 | 33 ± 1.9 | 30 ± 2 | 502 ± 10 | 499 ± 63 | ||
| Cl (ml/hr/kg) | 645 | 230 ± 24 | 246 ± 29 | 199 ± 7 | 200 ± 42 | ||||