Recovery of [14C]-trans-MSK in male JVC Fischer 344 rats
| Route | % of Radioactive Dose Recovered1-a | ||||
|---|---|---|---|---|---|
| Urine | Feces | Tissues | Trap and Skin Site1-b | Total Recovery1-c | |
| Intravenous (20 mg/kg) | 95.5 ± 1.5 | 2.7 ± 0.5 | 0.4 ± 0.03 | — | 98.6 ± 1.5 |
| Oral (200 mg/kg) | 96.6 ± 0.6 | 4.8 ± 0.3 | 0.1 ± 0.02 | — | 101.5 ± 0.9 |
| Topical (250 mg/kg) | 55.0 ± 11.5 | 1.2 ± 0.3 | 0.3 ± 0.1 | 39.8 ± 9.3 | 96.3 ± 2.1 |
↵1-a Mean % of dose ± SD,N = 3; oral and intravenous studies were conducted for 48 hr, whereas the topical study was conducted for 120 hr.
↵1-b Includes percutaneous skin trap, activated charcoal, and skin at the site of MSK application.
↵1-c Exhaled radioactive CO2 and organic accounted for <0.6% of the total dose; data not included in total recovery.