Enzyme Activity | P450 | t2-a | |
---|---|---|---|
N-Despropylation | Hydroxylation | ||
EthoxyresorufinO-deethylase | 1A2 | 6.1*** | NR |
Coumarin 7-hydroxylase | 2A6 | NR | NR |
Tolbutamide hydroxylase | 2C9/8 | NR | NR |
S-mephenytoin 4-hydroxylase | 2C19 | NR | 2.9* |
Bufuralol 1′-hydroxylase | 2D6 | NR | NR |
Chlorzoxazone 6-hydroxylase | 2E1 | NR | NR |
Testosterone 6β-hydroxylase | 3A | 2.8* | NR |
Lauric acid ω-hydroxylase | 4A11 | NR | NR |
*** p < 0.001; * p < 0.05.
NR No statistically significant or negative relationship in the model.
↵2-a t-statistic for the null hypothesis that the coefficient of the model is zero from the correlation of the production of each metabolite from ropinirole with known activities in nine human livers.