3-/4-MeSO2 substitution ratios and tissue/blood concentration ratios
| Ratio | TriCB | TetraCB | PentaCB | HexaCB |
|---|---|---|---|---|
| 3-/4-MeS-CB ratio in feces | 1.2 ± 0.3 | 0.76 ± 0.21 | 0.18 ± 0.04 | 0.14 ± 0.04 |
| 3-/4-MeSO2-CB ratio in tissues | ||||
| Adipose tissue | 1.4 ± 0.2 | 1.8 ± 0.31 | 0.43 ± 0.13 | 0.30 ± 0.06 |
| Kidney | 1.2 ± 0.2 | 1.4 ± 0.24 | 0.14 ± 0.05 | 0.10 ± 0.04 |
| Liver | 1.5 ± 0.3 | 1.3 ± 0.26 | 0.52 ± 0.12 | 0.23 ± 0.06 |
| Lung | 0.30 ± 0.1 | 0.16 ± 0.05 | 0.03 ± 0.02 | 0.01 ± 0.01 |
| Liver/blood ratio | ||||
| 3-MeSO2-CB | 11.8 ± 3.0 | 14.1 ± 2.5 | 5.9 ± 1.0 | 17.0 ± 4.5 |
| 4-MeSO2-CB | 16.5 ± 5.4 | 14.6 ± 3.8 | 3.6 ± 1.1 | 8.8 ± 2.5 |
| Lung/blood ratio | ||||
| 3-MeSO2-CB | 4.5 ± 1.2 | 3.4 ± 0.8 | 1.3 ± 0.3 | 5.7 ± 1.9 |
| 4-MeSO2-CB | 31.2 ± 5.5 | 25.2 ± 5.8 | 10.4 ± 3.2 | 51.2 ± 8.0 |
Rats were given TriCB, TetraCB, PentaCB, and HexaCB intraperitoneally (342 μmol/kg, each) and killed 96 hr after injection.
Values represent mean ± SD of 3–4 rats.