Inhibition of CYP isoforms by omeprazole and lansoprazole
| Assays | Inhibitors | Ki (μM) (SD) | Type of Inhibition | |
|---|---|---|---|---|
| Lineweaver-Burk Plot | Dixon Plot | |||
| 2C9 | Omeprazole | 40.1 (14.77) | 40.1 (2.10) | Competitive |
| Lansoprazole | 52.1 (1.41) | 49.1 (23.08) | Competitive | |
| 2C19 | Omeprazole | 3.1 (2.18) | 1.0 (0.0) | Competitive |
| Lansoprazole | 3.2 (1.29) | 3.4 (1.11) | Competitive | |
| 2D6 | Omeprazole | 240.7 (102.03) | 465.2 (396.47) | Competitive |
| Lansoprazole | 44.7 (22.02) | 40.3 (19.57) | Mixed | |
| 3A4 | Omeprazole | 84.4 (4.04) | 87.8 (8.09) | Noncompetitive |
| Lansoprazole | 170.4 (7.13) | 165.2 (35.55) | Noncompetitive | |