Treatment2-a | Testosterone Hydroxylase Activity2-b (pmol/min/mg microsomal protein) | |||
---|---|---|---|---|
2β- | 6β- | 7α- | 16β- | |
Control | 356 | 1430 | 157 | 25 |
Clonazepam (1000 ppm) | 312 | 1440 | 93 | 1180 |
Clonazepam (1800 ppm) | 342 | 1450 | 162 | 1820 |
Phenobarbital (500 ppm) | 873 | 4710 | 156 | 3260 |
↵2-a Three male F344/NCr rats were exposed to the indicated dietary concentrations of the agents for 5 days.
↵2-b Activities were determined in microsomes pooled from the individual groups. Hydroxylation of testosterone at the indicated positions has been shown to be associated with specific CYP subfamilies (2β, CYP3A; 6β, CYP3A; 2α, CYP2A, 16β, CYP2B).