Table 1

Sequences aligment between CYP101, CYP102 and some major human cytochrome P450s1-a

IsoformSequencesResidues
Predicted----G--->       <- H
Structure
CYP101LIPIIEQRRQKPGT----DAIS205–222
CYP102VDKIIADRKASGEQSD--DLLT217–236
CYP3A4VKRMKESRLEDTQKHRV-DFLQ253–273
CYP1A2LQKTVQEHYQDFDKNSVRDITG264–285
CYP2C9ILEKVKEHQESMDMNNPQDFID244–265
CYP2D6DELLTEHRMTWDPAQPPRDLTE252–273
CYP2E1VSERVKEHHQSLDPNCPRDLTD246–267

  • ↵1-a Sequence aligment of human cytochrome P450s near the loop region between helices G and H of CYP101 and CYP102 as proposed by Lewis (32).