Measured (uncorrected) intracellular decay half-time (tm) values for selected ddNTPs
| ddNTP | tm | Cell Type | Ref. |
|---|---|---|---|
| hr | |||
| AZT-TP | 2.1–3.4 | PHA-PBM | Törneviket al. (1) |
| AZT-TP | 3.3 | CEM | Ho & Hitchcock (8) |
| D4T-TP | 3.3 | CEM | Ho & Hitchcock (8) |
| D4T-TP | 3.5 | PHA-PBM | Zhu et al. (2) |
| 3TC-TP (β-d) | 3.5 | PHA-PBM | Cammack et al. (9) |
| ddGTP | 4.2 | MOLT-4 | Ahluwalia et al. (10) |
| ddGTP | 5.2 | CEM | Bondoc et al. (11) |
| ddCTP | 5.7 | MOLT-4 | Hao et al. (12) |
| ddCTP | 9.5 | CEM | Blakley et al. (13) |
| 3TC-TP (β-l) | 10.5–13.5 | PHA-PBM (HIV-infected) | Cammack et al. (9) |
| 3TC-TP (β-l) | 12–15.5 | PHA-PBM (uninfected) | Cammack et al. (9) |
| F-ddATP | 19 | MOLT-4 | Fig. 1 |
| F-ddATP | 20 | PBM (quiescent) | Ho et al. (5) |
| F-ddATP | 20 | U937 | Hitchcock et al. (14) |
| ddATP | 22 | MOLT-4 | Fig. 1 |
| ddATP | 43 | PHA-PBM | Gaoet al.1-a |
TP, triphosphate; ddCTP, 2′,3′-dideoxycytidine-5′-triphosphate.
↵1-a W.-Y. Gao, D. G. Johns, and H. Mitsuya, unpublished results.