Table 2

Products obtained after incubation of 500 μM 6-deoxypenciclovir^2-a with partially purified human, guinea pig, rabbit, and rat liver molybdenum hydroxylases and bovine milk xanthine oxidase for 15 min^2-b

Enzyme fraction	Penciclovir (nmol/mg protein/15 min)	8-Oxo-6-Deoxypenciclovir (nmol/mg protein/15 min)	8-Oxo-Penciclovir (nmol/mg protein/15 min)
Human	14.4 ± 13.8	0.4 ± 0.8	0.0
Guinea pig	430.2 ± 94.8	15.8 ± 3.4	<2
Rabbit^2-c	133.2	148.8	4.2
AO-active rat	79.1 ± 17.2	3.2 ± 1.8	<0.5
AO-deficient rat	36.8 ± 8.7	0.0	0.0
Bovine milk xanthine oxidase^2-c	101.2	0.0	0.0

↵2-a 500 μM 6-Deoxypenciclovir was incubated with all fractions except with human enzyme. In the latter case, the 6-deoxypenciclovir concentration. used was 50 μM.
↵2-b Mean ± SD (N = 3–4).
↵2-c Mean (N = 2).