Treatment | Pathway | CLint | Hepatocyte/MicrosomalCLint Ratio | |
---|---|---|---|---|
Microsomes | Hepatocytes | |||
ml/min/SRW | ||||
DEX | 4′-HDZ | 13.4 | 45.9 | 3.4 |
3-HDZ | 203.8 | 216.6 | 1.1 | |
NDZ | 30.3 | 34.1 | 1.1 | |
PB | 4′-HDZ | 11.7 | 24.5 | 2.1 |
3-HDZ | 30.0 | 87.8 | 2.9 | |
NDZ | 26.0 | 32.0 | 1.2 | |
UT4-a | 4′-HDZ | 26.4 | 69.4 | 2.6 |
3-HDZ | 12.6 | 20.7 | 1.7 | |
NDZ | 7.4 | 8.5 | 1.1 |
↵4-a In vitro data from Zomorodiet al. (9) scaled using the microsomal and hepatocyte scaling factors determined in tables 2 and 3.