Dose Volume | t1/2α | t1/2β | Vc | AUC | CLtotal |
---|---|---|---|---|---|
μl | hr | hr | ml/kg | ng-eq hr/ml | ml/hr/kg |
0 | 0.23 | 3.15 | 49.1 | 6.18 | 16.6 |
(0.05) | (0.49) | (4.1) | (1.16) | (3.0) | |
5 | 0.23 | 4.66 | 46.6 | 9.532-a | 10.52-a |
(0.05) | (1.04) | (3.0) | (0.37) | (0.4) | |
50 | 0.25 | 7.302-a | 46.6 | 15.02-a | 6.702-a |
(0.07) | (1.92) | (3.7) | (1.3) | (0.58) | |
500 | 0.17 | 3.81 | 51.6 | 4.73 | 21.4 |
(0.05) | (0.56) | (5.5) | (0.56) | (2.5) |
Each value represents the mean (SD) of 3 or 4 animals.
↵2-a Significant difference from control (p < 0.05).