Pharmacokinetic parameters of i.g. administration of EGCG (75 mg/kg) or DGT (200 mg/kg) in rats
| Parameter | Unit | EGCG | DGT | ||
|---|---|---|---|---|---|
| EGCG | EGC | EC | |||
| Ka | min−1× 10−3 | 1.4 ± 0.6 | 5.0 ± 2.6 | 11.6 ± 3.7 | 12.7 ± 5.5 |
| K 10 | min−1 × 10−3 | 57.5 ± 44.3 | 38.1 ± 24.1 | 21.8 ± 8.9 | 30.5 ± 22.3 |
| AUC | μg × min/ml | 17.4 ± 7.0 | 5.3 ± 1.7 | 277.1 ± 60.1 | 122.0 ± 16.7 |
| t 1/2(Ka) | min | 537.7 ± 189.4 | 165.2 ± 72.7 | 66.3 ± 27.7 | 67.1 ± 39.8 |
| t 1/2(K10) | min | 16.8 ± 9.3 | 32.1 ± 32.9 | 35.3 ± 11.7 | 30.1 ± 13.7 |
| t max | min | 85.5 ± 42.0 | 74.4 ± 30.1 | 64.2 ± 4.0 | 54.6 ± 8.5 |
| C max | ng/ml | 19.8 ± 3.5 | 16.3 ± 6.5 | 1,432.8 ± 245.5 | 685.4 ± 90.0 |
| F | % | 1.6 ± 0.6 | 0.1 ± 0.0 | 13.7 ± 3.0 | 31.2 ± 4.3 |
| Vd | dl/kg | 16.9 ± 0.9 | 0.9 ± 0.9 | 3.4 ± 1.1 | 5.9 ± 2.7 |
| CL | ml × min/kg | 69.8 ± 0.0 | 1.9 ± 0.0 | 6.8 ± 0.0 | 13.6 ± 0.0 |
Data are expressed as the mean ± SD of 3 or 4 rats. The equivalent dose of EGCG in DGT was 15 mg/kg.