Toxicokinetic parameters in male and female Sprague Dawley rats treated with 2,4-D (5 mg/kg, oral)
| Parameter | Males | Females |
|---|---|---|
| Rate of absorption (min−1) | 0.063 ± 0.028 | 0.065 ± 0.008 |
| Rate of elimination (min−1) | 0.020 ± 0.005 | 0.005 ± 0.000 |
| *** | ||
| Area under the curve (μg·min/ml) | 639.0 ± 71.6 | 4026.8 ± 139.0 |
| *** | ||
| Absorption half-life (min) | 11.1 ± 4.9 | 10.7 ± 1.4 |
| Elimination half-life (min) | 34.6 ± 9.2 | 139.4 ± 7.8 |
| *** | ||
| Time of maximal concentration (min) | 26.8 ± 4.8 | 42.9 ± 3.5 |
| *** | ||
| Maximal concentration (μg/ml) | 7.5 ± 0.8 | 16.2 ± 0.6 |
| *** |
*** Indicates a statistically significant difference between males and females by a Student’s t-test (p ≤ 0.05).
N = 5 for males and N = 4 for females.