Cumulative elimination of 2,4-D derived radioactivity in urine (% of administered dose)
| Species | Sex | Dose | 8 Hr | 24 Hr | 32 Hr | 48 Hr | 56 Hr | 72 Hr |
|---|---|---|---|---|---|---|---|---|
| F344 rat | M | 5 mg/kg | 78.0 ± 1.9 | 92.9 ± 1.7 | 93.2 ± 2.8 | 94.3 ± 2.6 | 94.5 ± 2.6 | 97.0 ± 2.0 |
| *** | *** | |||||||
| F344 rat | F | 5 mg/kg | 63.2 ± 6.2 | 85.1 ± 2.8 | 87.0 ± 2.9 | 88.3 ± 3.2 | 88.9 ± 3.2 | 92.2 ± 3.0 |
| F344 rat | M | 200 mg/kg | 31.2 ± 4.5 | 72.1 ± 6.5 | 82.5 ± 7.2 | 85.8 ± 7.2 | 86.2 ± 7.2 | 87.0 ± 7.2 |
| *** | ||||||||
| F344 rat | F | 200 mg/kg | 16.5 ± 2.9 | 60.4 ± 3.9 | 75.6 ± 6.8 | 79.2 ± 8.0 | 79.9 ± 8.2 | 81.0 ± 8.4 |
| B6C3F1 mice | M | 5 mg/kg | 17.6 ± 2.3 | 49.1 ± 7.1 | 56.4 ± 10.0 | 59.6 ± 12.0 | 60.0 ± 12.2 | 60.6 ± 12.4 |
| B6C3F1 mice | F | 5 mg/kg | 13.7 ± 7.0 | 38.9 ± 11.0 | 43.0 ± 10.4 | 53.0 ± 9.7 | 53.5 ± 9.8 | 54.2 ± 9.9 |
| B6C3F1 mice | M | 200 mg/kg | 12.7 ± 4.2 | 31.0 ± 6.1 | 40.3 ± 3.9 | 67.4 ± 3.3 | 71.1 ± 3.5 | 73.0 ± 3.6 |
| *** | *** | *** | *** | *** | *** | |||
| B6C3F1 mice | F | 200 mg/kg | 26.8 ± 1.7 | 68.2 ± 8.4 | 74.0 ± 8.0 | 88.8 ± 6.2 | 91.2 ± 6.7 | 93.7 ± 7.2 |
| Syr. hamster | M | 200 mg/kg | 4.9 ± 4.7 | 38.0 ± 12.2 | 44.4 ± 13.6 | 68.6 ± 2.4 | 79.1 ± 6.2 | 81.2 ± 7.03 |
| Syr. hamster | F | 200 mg/kg | 33.9 ± 12.1 | 64.7 ± 9.6 | 68.1 ± 9.6 | 69.4 ± 9.6 | 70.2 ± 9.5 | 70.9 ± 9.6 |
*** Significant difference between sexes at same dose and time point by a Student’s t-test (p ≤ 0.05).
N = 3 in all cases except male hamsters (N = 2).