Ifosfamide and its metabolites in perfusate and urine
| IF | N2D | N3D | IPM | |
|---|---|---|---|---|
| Arterial perfusate (μmol/L) | 548 ± 132 | 0.42 ± 0.15 | 0.26 ± 0.06 | 0.46 ± 0.14 |
| Venous perfusate (μmol/L) | 502 ± 1252-a | 0.47 ± 0.19 | 0.23 ± 0.03 | 0.79 ± 0.232-a |
| Urine (μmol/L) | 1,230 ± 479 | 1.02 ± 0.33 | 0.54 ± 0.05 | 1.10 ± 0.21 |
| Urinary excretion (nmol/30 min) | 3,481 ± 466 | 3.2 ± 1.1 | 2.6 ± 0.5 | 5.5 ± 0.8 |
| CLtotal (ml/min) | 3.5 ± 0.6 | −1.3 ± 2.6 | −8.7 ± 6.9 | −24.7 ± 7.42-b |
| CLurine (ml/min) | 0.23 ± 0.03 | 0.32 ± 0.10 | 0.27 ± 0.05 | 0.44 ± 0.09 |
| CLnonurine (ml/min) | 3.3 ± 0.5 | −1.7 ± 2.7 | −8.9 ± 6.9 | −25.0 ± 7.22-b |
Measurements were performed during a 30-min experimental period when IF (77 μmol) was present in the perfusate. Results are mean ± SE of four experiments. CLtotal, total renal clearance; CLurine, urinary clearance; CLnonurine, CLtotal − CLurine.
↵2-a Significantly different from corresponding arterial perfusate concentration, p < 0.05.
↵2-b Significantly less than zero,p < 0.05.