CYP | Enzyme Activity | t2-a | |||
---|---|---|---|---|---|
4OHC | 5OHC | 8OHC | ODMC | ||
R(+)-carvedilol | |||||
1A2 | Caffeine N3-demethylase | NR | NR | NR | NR |
2A6 | Coumarin 7-hydroxylase | NR | NR | NR | NR |
2C9 | Tolbutamide hydroxylase | NR | NR | NR | 2.32* |
2C19 | S-mephenytoin 4-hydroxylase | NR | NR | NR | NR |
2D6 | Bufurolol 1′-hydroxylase | 4.56*** | 9.24*** | NR | 4.24** |
2E1 | Lauric acid ω-1 hydroxylase | NR | 3.97** | NR | 2.31* |
3A | Cyclosporine oxidase | NR | NR | 4.56*** | NR |
4A | Lauric acid ω-hydroxylase | NR | NR | NR | NR |
S(−)-carvedilol | |||||
1A2 | Caffeine N3-demethylase | NR | NR | 3.38* | NR |
2A6 | Coumarin 7-hydroxylase | NR | NR | NR | NR |
2C9 | Tolbutamide hydroxylase | 3.62** | NR | NR | 5.29*** |
2C19 | S-mephenytoin 4-hydroxylase | NR | NR | NR | NR |
2D6 | Bufurolol 1′-hydroxylase | 15.44*** | 12.23*** | NR | 2.77* |
2E1 | Lauric acid ω-1 hydroxylase | NR | 3.14* | NR | NR |
3A | Cyclosporine oxidase | NR | NR | 3.83** | NR |
4A | Lauric acid ω-hydroxylase | NR | 2.09* | NR | NR |
↵2-a t-statistic for the null hypothesis that the coefficient of the model is zero.
* p < 0.05; ** p < 0.001; *** p < 0.0001.
NR, No or negative relationship in the model.