Inhibitor | P450 Inhibited | Substrate | % Inhibition | |||
---|---|---|---|---|---|---|
4OHC | 5OHC | 8OHC | ODMC | |||
Quinidine | 2D6 | R(+) | 38, 57, 66 | 25, 36, 44 | 15, 9, 24 | 9, 19, 21 |
S(−) | 10, 66, 59 | 0, 42, 30 | 0, 38, 21 | 0, 0, 2 | ||
Ketoconazole | 3A | R(+) | 17, 5, 8 | 0, 0, 0 | 40, 6, 0 | 16, 10, 0 |
S(−) | 0, 0, 11 | 0, 6, 0 | 0, 20, 19 | 6, 6, 0 | ||
Sulphaphenazole | 2C9 | R(+) | 5, 11, 10 | 8, 4, 9 | 0, 0, 0 | 35, 18, 12 |
S(−) | 22, 0, 0 | 14, 2, 0 | 14, 0, 0 | 44, 30, 18 | ||
Furafylline | 1A2 | R(+) | 0, 0, 0 | 0, 0, 0 | 100, 8, 0 | 2, 0, 2 |
S(−) | 18, 19, 26 | 0, 6, 2 | 40, 50, 32 | 2, 2, 0 |