Urinary recovery and pharmacokinetic parameters forl-767,679 and prodrugs II and III in dogs
| Compound Administered | Dose | Urinary Recovery | F679 (prodrug po) | F | ||
|---|---|---|---|---|---|---|
| l-767,679 | II | III | ||||
| mg/kg | % of dose | % | ||||
| l-767,679 | 0.4 | 15 ± 2 | — | — | — | 18 ± 1 |
| II | 0.5 | 34 ± 1 | 2 ± 1 | — | 41 ± 4 | 21 ± 8 |
| III | 0.5 | 22 ± 1 | — | 5 ± 2 | 27 ± 3 | 38 ± 5 |
Results (means ± SD, N = 4) were obtained after po administration