Urinary recovery and pharmacokinetic parameters forl-767,679 and prodrugs II and III in monkeys
| Compound Administered | Dose | Urinary Recovery | F679 (prodrug po) | F | ||
|---|---|---|---|---|---|---|
| l-767,679 | II | III | ||||
| mg/kg | % of dose | % | ||||
| l-767,679 | 1.25 | 6 ± 3 | — | — | — | 7 ± 4 |
| II | 0.5 | 12 ± 2 | 0.6 ± 0.2 | — | 14 ± 2 | 3 ± 2 |
| III | 0.5 | 9 ± 9 | — | 1 ± 0.5 | 10 ± 10 | 5 ± 3 |
Results (means ± SD, N = 4) were obtained after po administration.