Table 1

Mean pharmacokinetic parameters of DW116

ParametersDose (mg/kg), Route
4, iv4, po8, po20, po
C max(μg/ml)3.54  ± 0.163.44  ± 0.337.62  ± 0.1214.83  ± 1.74
t max(hr)0.081-a 0.38  ± 0.060.46  ± 0.110.92  ± 0.47
t ½ (hr)3.9  ± 0.33.8  ± 0.53.1  ± 0.63.6  ± 0.2
AUC (μg·hr/ml)14.7  ± 1.417.8  ± 2.839.1  ± 7.175.6  ± 3.7
MRT (hr)5.1  ± 0.65.8  ± 0.54.7  ± 0.75.4  ± 0.3
CLT 1-b (ml/hr/kg) 274  ± 27239  ± 54221  ± 55266  ± 22
Vss 1-b (liters/kg) 1.63  ± 0.221.35  ± 0.097  ± 0.051.43  ± 0.01

  • Cmax, maximum concentration;tmax, time to maximum concentration;t½, half-life; MRT, mean residence time; iv, intravenous; po, oral.

  • ↵1-a The first sampling time.

  • ↵1-b The fraction of dose absorbed was assumed to be unity, because the oral bioavailability of DW116 was >100%.