Metabolite | Correlation (r2) | |||
---|---|---|---|---|
CYP3A4 | CYP2C9 | CYP2A6 | ||
T6H2-b | NNO2-b | TMH2-b | C7H2-b | |
M2a | 0.8052-c | 0.8252-c | 0.0876 | 0.445 |
M2b | 0.6122-d | 0.6362-d | 0.0997 | 0.405 |
M5a | 0.9132-c | 0.9322-c | 0.0647 | 0.538 |
M5b | 0.9172-c | 0.9382-c | 0.0683 | 0.556 |
M6a/b | 0.483 | 0.501 | 0.533 | 0.544 |
↵2-a Human liver microsomes obtained from 12 individual donors were used.
↵2-b Marker activities: T6H, testosterone 6β-hydroxylation; NNO, nifedipine N-oxidation; TMH, tolbutamide methyl-hydroxylation; C7H, coumarin 7-hydroxylation.
↵2-c Significant correlation was obtained (p < 0.001).
↵2-d Significant correlation was obtained (p < 0.005).