Concentrations of drug-related radioactivity (mean ± SD) in selected tissues and organs of rats after a 10 mg/kg single oral dose of [14C]atevirdine mesylate
| Tissue/Organ | Sprague-Dawley | Long-Evans | ||||||
|---|---|---|---|---|---|---|---|---|
| Male | Female | Pregnant | Male | |||||
| 1 hr | 24 hr | 1 hr | 24 hr | 1 hr | 24 hr | 1 hr | 24 hr | |
| Adrenal cortex | 11.8 ± 3.5 | 0.40 ± 0.09 | 14.9 ± 2.6 | 0.40 ± 0.21 | 8.04 | 0.79 | 3.90 ± 1.20 | 0.30 ± 0.13 |
| Blood | 5.39 ± 1.34 | 0.18 ± 0.02 | 3.92 ± 0.44 | 0.24 ± 0.21 | 3.06 | 0.40 | 2.15 ± 0.12 | 0.13 ± 0.04 |
| Bone marrow | 3.02 ± 0.50 | 0.06 ± 0.01 | 3.84 ± 0.27 | 0.09 ± 0.04 | 1.88 | 0.13 | 1.40 ± 0.50 | 0.05 ± 0.02 |
| Brain | 2.86 ± 1.34 | 0.01 ± 0.01 | 3.80 ± 0.42 | ND1-a | 2.30 | ND | 0.79 ± 0.37 | 0.01 ± 0.01 |
| Brown fat | 7.50 ± 2.29 | 0.17 ± 0.02 | 13.8 ± 3.0 | 0.18 ± 0.14 | 7.87 | 0.18 | 3.51 ± 1.25 | 0.14 ± 0.05 |
| Fetal blood | — | — | — | — | 11.8 | 0.37 | — | — |
| Fetal brain | — | — | — | — | 2.01 | 0.06 | — | — |
| Fetal kidney | — | — | — | — | 17.0 | 0.33 | — | — |
| Fetal liver | — | — | — | — | 9.45 | 0.30 | — | — |
| Fetal lung | — | — | — | — | 8.30 | 0.18 | — | — |
| Fetal muscle | — | — | — | — | 11.9 | 0.34 | — | — |
| Fetal myocardium | — | — | — | — | 4.46 | 0.14 | — | — |
| Kidney cortex | 10.6 ± 2.3 | 0.66 ± 0.10 | 10.6 ± 0.5 | 0.37 ± 0.18 | 4.04 | 0.76 | 4.75 ± 1.00 | 0.52 ± 0.03 |
| Liver | 29.6 ± 6.8 | 1.91 ± 0.83 | 27.8 ± 4.1 | 1.27 ± 0.63 | 12.5 | 2.32 | 14.4 ± 0.1 | 1.77 ± 0.00 |
| Lung | 4.93 ± 0.46 | 0.16 ± 0.01 | 5.13 ± 0.40 | 0.19 ± 0.18 | 3.03 | 0.32 | 2.61 ± 0.35 | 0.11 ± 0.02 |
| Myocardium | 5.19 ± 1.15 | 0.16 ± 0.04 | 6.59 ± 0.41 | 0.15 ± 0.11 | 3.34 | 0.20 | 2.08 ± 0.63 | 0.11 ± 0.02 |
| Ovary | — | — | 5.46 ± 0.08 | 0.13 ± 0.10 | 4.43 | 0.22 | — | — |
| Pancreas | 4.94 ± 1.03 | 0.08 ± 0.01 | 7.02 ± 0.79 | 0.08 ± 0.08 | 3.56 | 0.17 | 2.36 ± 0.94 | 0.08 ± 0.02 |
| Pituitary | 6.37 ± 2.57 | 0.08 ± 0.01 | 6.39 ± 0.54 | 0.79 ± 0.37 | 3.65 | 0.17 | 1.84 ± 0.61 | 0.09 ± 0.05 |
| Placenta | — | — | — | — | 3.52 | 0.28 | — | — |
| Skeletal muscle | 2.90 ± 0.51 | 0.06 ± 0.00 | 3.66 ± 0.35 | 0.04 ± 0.04 | 1.52 | 0.06 | 1.18 ± 0.47 | 0.06 ± 0.02 |
| Skin | 3.57 ± 0.68 | 0.17 ± 0.05 | 3.66 ± 0.85 | 0.22 ± 0.07 | 1.47 | 0.15 | 2.58 ± 0.72 | 1.70 ± 0.19 |
| Spleen | 3.05 ± 0.74 | 0.09 ± 0.01 | 3.77 ± 0.28 | 0.06 ± 0.06 | 1.72 | 0.14 | 1.35 ± 0.48 | 0.09 ± 0.02 |
| Testis | 2.76 ± 0.70 | 0.04 ± 0.00 | — | — | — | — | 0.66 ± 0.03 | 0.04 ± 0.02 |
| Thyroid | 5.77 ± 2.43 | 1.25 ± 0.37 | 6.23 ± 0.45 | 0.85 ± 0.23 | 2.96 | 1.94 | 1.98 ± 0.49 | 1.25 ± 0.38 |
| Uveal tract | — | — | — | — | — | — | 10.8 ± 2.4 | 5.55 ± 0.43 |
↵1-a ND, not detected.