Characteristics of human liver microsomes
| 11-a | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |
|---|---|---|---|---|---|---|---|---|
| Age (years) | 64 | 54 | 48 | 41 | 80 | 51 | 45 | 54 |
| Gender | F1-b | F | M | F | M | F | M | M |
| Smoking | − | + | − | − | − | − | NA | − |
| CYP1A2 content (units)1-c | 14 | 38 | <5 | 22 | 15 | <5 | 15 | 30 |
| CYP3A4 content (units)1-c | 60 | 59 | 30 | 61 | 52 | 95 | 53 | 61 |
| CYP2E content (units)1-c | 31 | 26 | 28 | 44 | 53 | 55 | 47 | 32 |
| Caffeine N 3-demethylation (pmol/min/mg)1-d | 123 | 290 | 48 | 275 | ND | 15 | 68 | 189 |
↵1-a Patient number.
↵1-b F, female; M, male; NA, not available; ND, not determined.
↵1-c Arbitrary units, determined by densitometric analysis of immunoblots.
↵1-d Activities (expressed as picomoles of metabolites per minute per milligram of protein) were determined, in two different laboratories, for samples 1–4 and 6–8.