Table 1

Excretion of ¹⁴C-radioactivity during mouse, rat, and dog studies

	Mouse		Rat		Dog
	Oral, 10 mg/kg		Oral, 300 mg/kg		Oral, 1 mg/kg, Male	Oral, 40 mg/kg		Oral, 14 days at 40 mg/kg		iv, 1 mg/kg, Male	Oral, 1 mg/kg, Male	Oral, 5 mg/kg, Male
	Male	Female	Male	Female	Oral, 1 mg/kg, Male	Male	Female	Male	Female	iv, 1 mg/kg, Male	Oral, 1 mg/kg, Male	Oral, 5 mg/kg, Male
Time after final dose (hr)	72	72	72	72	48	168	168	192	192	120	120	120
Recovery (% of total radioactivity)
Urine	0.35 ± 0.02	0.21 ± 0.06	0.21 ± 0.03	0.18 ± 0.07	0.7 ± 0.2	0.05 ± 0.00	0.10 ± 0.04	0.05 ± 0.02	0.06 ± 0.01	1.21 ± 0.18	0.70 ± 0.12	1.02 ± 0.30
Feces	76.9 ± 4.2	84.8 ± 0.9	89.7 ± 1.13	86.5 ± 1.18	76.7 ± 0.1	99.3 ± 2.0	100 ± 1	97.4 ± 0.4	97.8 ± 0.8	91.2 ± 2.19	94.5 ± 0.6	89.7 ± 0.7
Cage wash	12.3 ± 3.4	6.79 ± 0.59	4.73 ± 0.87	4.14 ± 1.46	2.1 ± 0.4	0.03 ± 0.01	0.09 ± 0.06	0.19 ± 0.06	0.11 ± 0.05	—^1-a	—^1-a	—^1-a
Total	89.5 ± 0.8	91.8 ± 1.2	94.6 ± 0.4	90.8 ± 0.7	79.5 ± 0.5	99.4 ± 1.9	100 ± 1	97.4 ± 0.4	97.9 ± 0.7	92.4 ± 2.0	95.2 ± 0.5	90.7 ± 0.7