Mouse | Rat | Dog | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Oral, 10 mg/kg | Oral, 300 mg/kg | Oral, 1 mg/kg, Male | Oral, 40 mg/kg | Oral, 14 days at 40 mg/kg | iv, 1 mg/kg, Male | Oral, 1 mg/kg, Male | Oral, 5 mg/kg, Male | |||||
Male | Female | Male | Female | Male | Female | Male | Female | |||||
Time after final dose (hr) | 72 | 72 | 72 | 72 | 48 | 168 | 168 | 192 | 192 | 120 | 120 | 120 |
Recovery (% of total radioactivity) | ||||||||||||
Urine | 0.35 ± 0.02 | 0.21 ± 0.06 | 0.21 ± 0.03 | 0.18 ± 0.07 | 0.7 ± 0.2 | 0.05 ± 0.00 | 0.10 ± 0.04 | 0.05 ± 0.02 | 0.06 ± 0.01 | 1.21 ± 0.18 | 0.70 ± 0.12 | 1.02 ± 0.30 |
Feces | 76.9 ± 4.2 | 84.8 ± 0.9 | 89.7 ± 1.13 | 86.5 ± 1.18 | 76.7 ± 0.1 | 99.3 ± 2.0 | 100 ± 1 | 97.4 ± 0.4 | 97.8 ± 0.8 | 91.2 ± 2.19 | 94.5 ± 0.6 | 89.7 ± 0.7 |
Cage wash | 12.3 ± 3.4 | 6.79 ± 0.59 | 4.73 ± 0.87 | 4.14 ± 1.46 | 2.1 ± 0.4 | 0.03 ± 0.01 | 0.09 ± 0.06 | 0.19 ± 0.06 | 0.11 ± 0.05 | —1-a | —1-a | —1-a |
Total | 89.5 ± 0.8 | 91.8 ± 1.2 | 94.6 ± 0.4 | 90.8 ± 0.7 | 79.5 ± 0.5 | 99.4 ± 1.9 | 100 ± 1 | 97.4 ± 0.4 | 97.9 ± 0.7 | 92.4 ± 2.0 | 95.2 ± 0.5 | 90.7 ± 0.7 |
Values are means ± SE.
↵1-a Added to feces.