Sample | Rat | Dog | ||||
---|---|---|---|---|---|---|
iv, 1 mg/kg, 0–96 hr (N = 5) | Oral, 1 mg/kg, 0–96 hr (N = 4) | Oral, 5 mg/kg, 0–96 hr (N = 4) | iv, 1 mg/kg, 48 hr3-a (N = 2) | Oral, 1 mg/kg, 72 hr3-a (N = 2) | Oral/Bile before Dose, 1 mg/kg, 72 hr3-a (N = 1) | |
% | ||||||
Bile | 79.0 ± 2.4 | 54.3 ± 4.3 | 40.7 ± 4.9 | 88.2 | 31.9 | 59.2 |
Urine | 0.5 ± 0.1 | 1.1 ± 0.3 | 0.8 ± 0.3 | 1.29 | 0.57 | 2.71 |
Feces | 2.0 ± 0.1 | 38.3 ± 4.4 | 44.5 ± 4.1 | 2.69 | 53.7 | 34.7 |
Total | 81.5 ± 2.5 | 93.6 ± 2.0 | 85.9 ± 1.1 | 92.2 | 86.2 | 96.6 |
Absorption3-b | 69.6 ± 5.2 | 52.1 ± 5.9 | 36.3 | 68.5 |