Table 1

Effects of pretreatment with various inducers on P450 content, and 7α-OH- and 7β-OH-Δ8-THC MALCO activities in mouse liver microsomes

TreatmentP450 ContentMALCO Activity
7α-OH-Δ8-THC7β-OH-Δ8-THC
nmol/mg protein nmol/min/mg protein
Control (none)0.64  ± 0.050.28  ± 0.040.52  ± 0.12
(100)(100)(100)
Dexamethasone1.67  ± 0.111-b 3.35  ± 0.201-b 6.78  ± 0.711-b
(261)(1193)(1311)
Phenobarbital1.25  ± 0.021-b 1.32  ± 0.171-b 1.57  ± 0.461-a
(195)(471)(304)
3-Methylcholanthrene0.69  ± 0.100.20  ± 0.030.37  ± 0.08
(108)(70)(72)
Acetone1.04  ± 0.061-b 0.19  ± 0.030.13  ± 0.031-b
(163)(67)(25)

  • Each value represents the mean ± S.E. of four determinations. Numbers in parentheses are relative value (%) to the control.

  • ↵1-a Significantly different from the control (p < 0.05).

  • ↵1-b Significantly different from the control (p < 0.01).