Pharmacokinetic parameters obtained after iv administration of a 1 mg/kg dose of MEN 11420 or MEN 10627 to unanesthetized rats
| Parameter | MEN 11420 | MEN 10627 |
|---|---|---|
| t 1/2,α(min) | 4.6 ± 2.3 | 1.5 ± 0.6 |
| t 1/2,β (min) | 44 ± 32-a | 16.5 ± 1.2 |
| AUC (μg · min/ml) | 285 ± 122-a | 129 ± 31 |
| Volume of distribution (ml/kg) | 225 ± 27 | 247 ± 30 |
| Clearance (ml/min/kg) | 3.5 ± 0.2 | 10 ± 4 |
Means ± SE are reported (N = 4).
↵2-a p < 0.05 vs. MEN 10627.