Effects of pretreatment with bezafibrate or fenofibrate on pharmacokinetic parameters of benzoate elimination in rats
| Pretreatment1-a | Glycine1-b | Benzoate1-c | Vd | Kel | t1/2 | CLb |
|---|---|---|---|---|---|---|
| mmol/kg | mmol/kg | liters/kg | hr−1 | min | ml/min · kg | |
| None | 0 | 1 | 0.370 ± 0.01 | 1.04 ± 0.06 | 40.5 ± 2.7 | 6.43 ± 0.40 |
| Bezafibrate | 0 | 1 | 0.381 ± 0.03 | 1.30 ± 0.10 | 33.1 ± 2.6 | 8.07 ± 0.391-d |
| Fenofibrate | 0 | 1 | 0.320 ± 0.011-d | 2.03 ± 0.061-d | 20.6 ± 0.71-d | 10.8 ± 0.421-d |
| None | 0 | 2 | 0.418 ± 0.01 | 0.396 ± 0.02 | 107 ± 5.4 | 2.76 ± 0.16 |
| Bezafibrate | 0 | 2 | 0.421 ± 0.01 | 0.492 ± 0.041-d | 87.1 ± 6.91-d | 3.44 ± 0.251-d |
| Fenofibrate | 0 | 2 | 0.433 ± 0.01 | 0.576 ± 0.031-d | 73.5 ± 4.41-d | 4.15 ± 0.211-d |
| None | 5 | 2 | 0.512 ± 0.02 | 0.792 ± 0.10 | 61.5 ± 9.6 | 6.68 ± 0.92 |
| Bezafibrate | 5 | 2 | 0.414 ± 0.041-d | 1.39 ± 0.221-d | 36.3 ± 6.71-d | 8.88 ± 1.00 |
| Fenofibrate | 5 | 2 | 0.357 ± 0.021-d | 1.99 ± 0.191-d | 23.2 ± 3.41-d | 11.39 ± 0.731-d |
Values are the mean ± SE for 6–10 rats.
↵1-a Rats were fed ground chow or ground chow containing bezafibrate or fenofibrate (2.5 mmol/kg of feed) for 10 days.
↵1-b Pretreated and anesthetized rats were or were not injected with glycine (5 mmol/kg, iv) 15 min before benzoate administration.
↵1-c Pretreated and anesthetized rats were injected iv with sodium benzoate, at the doses indicated.
↵1-d Significantly different (p < 0.05) from the respective value for rats not fed fibrate but injected with the same dose of benzoate and glycine.