Pharmacokinetic parameters of L-732,531 in intravenously dosed rats
| Dose | AUC | Clearance | t1/2 | Vdss |
|---|---|---|---|---|
| mg/kg | ng · hr/ml | ml/min/kg | hr | l/kg |
| Plasma | ||||
| 0.21-a | 56 | 60 | —1-c | 21.0 |
| 1.01-a | 506 | 33 | 4.9 | 10.5 |
| Blood | ||||
| 0.21-a | 60 | 56 | —1-c | 16.4 |
| 0.31-b | 103 ± 7 | 48 ± 4 | 5.6 | 17.8 ± 2.7 |
| 1.01-a | 488 | 34 | 4.9 | 11.2 |
| 3.01-b | 1715 ± 547 | 31 ± 7 | 5.9 | 11.0 ± 2.9 |
↵1-a This was a serial sacrifice study, in which blood was obtained from three different rats at each time point. The pharmacokinetic parameters were calculated from the mean concentrations of L-732,531.
↵1-b Five surgically prepared rats at each dose were serially bled. Mean ± SD values are reported.
↵1-c Not calculated. The elimination rate constants obtained from the 1 mg/kg dose were used for extrapolation purposes.