Pharmacokinetics of L-732,531 in orally dosed rats
| Dose | AUC | Cmax | tmax |
|---|---|---|---|
| mg/kg | ng · hr/ml | ng/ml | hr |
| Plasma | |||
| 1 | 29 | 10 ± 6 | 0.5 |
| 5 | 466 | 129 ± 68 | 1.0 |
| 15 | 2832 | 304 ± 179 | 6.0 |
| Blood | |||
| 5 | 359 | 102 ± 50 | 1.0 |
This was a serial sacrifice study, in which blood was obtained from three different rats at each time point. The pharmacokinetic parameters were calculated from the mean concentrations of L-732,531.