Excretion of radioactivity in urine and feces after oral administration of [3H]Org 30659 to rats and monkeys
| Time | Excretion | |||
|---|---|---|---|---|
| Rats (N= 3) | Monkeys (N = 4) | |||
| Urine | Feces | Urine | Feces | |
| hr | % | |||
| 0–24 | 30.3 ± 6.3 | 17.4 ± 5.9 | 14.2 ± 9.0 | 2.5 ± 4.9 |
| 24–48 | 9.0 ± 2.7 | 20.2 ± 11.5 | 7.0 ± 2.2 | 10.9 ± 13.1 |
| 48–72 | 3.0 ± 3.2 | 9.4 ± 6.5 | 4.1 ± 3.3 | 18.3 ± 12.9 |
| 72–96 | 0.4 ± 0.2 | 2.9 ± 2.6 | 1.2 ± 0.7 | 7.0 ± 5.6 |
| 96–120 | 0.2 ± 0.1 | 0.6 ± 0.5 | 0.5 ± 0.3 | 3.7 ± 3.6 |
| 120–144 | 0.2 ± 0.1 | 0.1 ± 0.1 | 0.3 ± 0.2 | 1.0 ± 0.7 |
| 144–168 | 0.1 ± 0.0 | 0.0 ± 0.1 | 0.1 ± 0.1 | 0.5 ± 0.4 |
| 0–168 | 43.0 ± 2.3 | 50.8 ± 0.9 | 27.3 ± 4.7 | 43.9 ± 16.5 |
| Total | 93.8 ± 3.2 | 71.2 ± 14.2 | ||
Data are expressed as percentages of the administered dose (mean ± SD of individual data).