Parameters3-a | Rats (100 mg/kg) | Monkeys (25 mg/kg) | Dogs (15 mg/kg) | Humans (15 mg) | ||||
---|---|---|---|---|---|---|---|---|
I | II | I | II | I | II | I | II | |
C max(ng/ml) | 531 | 19.9 | 77.5 | 20.4 | 110 | 121 | 2.0 | 0.73 |
t max(hr) | 4.8 | 5.3 | 4.7 | 9.7 | 3.0 | 0.5 | 2.5 | 3.5 |
AUC0–tldc (ng · hr/ml) | 4420 | 143 | 974 | 296 | 365 | 1360 | 9.39 | 4.10 |
CL/F(ml/min/kg) | 589 | 428 | 685 | 491 |
↵3-a Cmax, maximal observed plasma concentration, tmax, time of the maximal plasma concentration; AUC0–tldc, AUC from time 0 to the time of the last detectable concentration; CL/F, oral CL.