Table 2

Clearance values for HSR-903 (S-isomer), its R-isomer, and their conjugates after 5 mg/kg iv bolus administration to SDR and EHBR

Clearance
SDREHBR
ml/min/kg
Intact
 CL bile
  S-Isomer1.94  ± 0.130.72  ± 0.062-a
  R-Isomer6.02  ± 3.092-b 0.88  ± 0.152-a
 CL urine
  S-Isomer2.57  ± 0.612.48  ± 1.43
  R-Isomer4.27  ± 4.623.04  ± 1.50
Conjugate
 CL bile
  S-Isomer7.46  ± 0.010.17  ± 0.012-a
  R-Isomer21.53  ± 1.562-b 0.23  ± 0.072-a
 CL urine
  S-Isomer1.68  ± 1.562.47  ± 1.24
  R-Isomer1.16  ± 0.424.92  ± 3.36

  • Each value represents the mean ± SE from three or four experiments.

  • ↵2-a Significant difference (p < 0.05) between SDR and EHBR.

  • ↵2-b Significant difference (p < 0.05) between the S-isomer and the R-isomer.