Michaelis-Menten parameters KM,app andVmax, in vitro CLint, and scaledin vivo CLint values for selected progestins
| Compound | Vmax | KM,app | In Vitro CLint | Scaled In Vivo CLint | Calculated f |
|---|---|---|---|---|---|
| nmol/min/mg | μM | ml/min/mg | liters/hr | % | |
| 3-Keto-desogestrel | 1.450 | 10.67 | 0.136 | 571 | 79 |
| Desogestrel | 5.14 | 54.11 | 0.095 | 399 | |
| Norgestimate | 0.924 | 2.992 | 0.309 | 1297 | |
| Levonorgestrel | 3.082 | 38.51 | 0.080 | 336 | 91 |
| Gestodene | 3.031 | 51.25 | 0.059 | 248 | 93 |
| Norethisterone | 5.695 | 48.27 | 0.118 | 496 | 63 |
| Dienogest | 1.744 | 38.32 | 0.046 | 191 | 61 |
Bioavailability (f) was calculated according to eqs. 8and 12.