Study Day | AUCt (hr · ng/ml) | Cmax (ng/ml) | t1/2(hr) | CL/F (liter/hr) |
---|---|---|---|---|
1 | 1373 ± 912 | 311 ± 232 | 3.0 ± 1.21-a | 502 ± 283 |
(754, 1779) | (167, 397) | (2.0, 3.8) | (281, 664) | |
4 | 402 ± 251 | 148 ± 93 | 3.8 ± 2.01-a | 3033 ± 4636 |
(147, 605) | (76, 199) | (2.3, 5.2) | (826, 3398) | |
7 | 346 ± 398 | 110 ± 104 | 4.8 ± 5.01-b | 8048 ± 12895 |
(61, 485) | (36, 151) | (1.2, 9.8) | (1031, 8190) | |
21 | 862 ± 5031-c | 195 ± 1261-c | 2.7 ± 0.91-c | 553 ± 1861-c |
(137, 2180) | (61, 361) | (1.8, 3.6) | (364, 767) |