Tissue | Tmax | Cmax | AUC0–t | AUC0–∞ | Kel | t1/2 |
---|---|---|---|---|---|---|
hr | μg-eq/g | μg-eq·hr/g | μg-eq·hr/g | hr−1 | hr | |
Eye | 4 | 3.52 ± 0.87 | 54 | NC1-a | NC1-a | NC1-a |
Brain | 4 | 1.35 ± 0.28 | 21 | NC1-a | NC1-a | NC1-a |
Lung | 4 | 47.20 ± 11.57 | 784 | 798 | 0.0858 | 8.1 |
Heart | 4 | 18.94 ± 4.70 | 349 | 359 | 0.0763 | 9.1 |
Pancreas | 4 | 15.96 ± 3.81 | 416 | 436 | 0.0627 | 11.1 |
Spleen | 4 | 12.68 ± 1.08 | 200 | 206 | 0.0742 | 9.3 |
Adrenal glands | 4 | 19.05 ± 2.80 | 266 | NC1-a | NC1-a | NC1-a |
Kidney | 4 | 69.14 ± 16.76 | 1572 | 1581 | 0.0544 | 12.8 |
Testes | 4 | 13.69 ± 3.71 | 344 | 355 | 0.0151 | 46.0 |
Light skin | 4 | 16.01 ± 2.86 | 345 | 357 | 0.0357 | 19.4 |
Dark skin | 4 | 18.60 ± 7.35 | 430 | 450 | 0.0329 | 21.1 |
Sciatic nerve | 4 | 7.37 ± 1.12 | 227 | 288 | 0.0321 | 21.6 |
Muscle | 4 | 7.52 ± 1.74 | 133 | 139 | 0.0686 | 10.1 |
Urinary bladder | 8 | 21.48 ± 3.45 | 554 | 572 | 0.0702 | 9.9 |
Whole blood | 4 | 54.97 ± 8.84 | 1027 | 1049 | 0.0809 | 8.6 |
Plasma | 4 | 104.8 ± 22.1 | 1803 | 1836 | 0.0846 | 8.2 |
Red blood cells | 4 | 20.34 ± 6.07 | 339 | 346 | 0.0808 | 8.6 |
Stomach | 4 | 90.72 ± 6.63 | 1194 | 1217 | 0.0839 | 8.3 |
Liver | 4 | 145.6 ± 9.9 | 3523 | 3529 | 0.0313 | 22.2 |
Jejunum | 4 | 53.12 ± 21.29 | 1028 | 1059 | 0.0739 | 9.4 |
Ileum | 4 | 211.2 ± 105.0 | 3001 | 3007 | 0.0663 | 10.5 |
Large Intestine | 8 | 110.3 ± 42.8 | 3123 | 3132 | 0.0652 | 10.6 |
Fat | 4 | 7.69 ± 4.07 | 121 | 129 | 0.0611 | 11.3 |
AUC0–t represents the AUC from time 0 to the last quantifiable time point. The elimination rate constant (kel) and t1/2 values were estimated from mean tissue concentrations over the interval starting at 4 hr for all tissues, except urinary bladder (8 hr), large intestine (24 hr), testes, and liver (48 hr), and ending at the last quantifiable time point.Tmax, time of Cmax.
↵1-a AUC0–∞, kel, andt1/2 could not be calculated for these tissues.