Rat No. | Gender | Radioactivity Attributable to Each Metabolite | |||||
---|---|---|---|---|---|---|---|
Metabolites 2 & 3 | Metabolite 5 | Metabolites 8 & 9 | Metabolite 10 | Metabolite 18 | Zopolrestat | ||
% of total | |||||||
135-a | M | 7.8 | 2.2 | 0.0 | 5.5 | 22.3 | 60.1 |
14 | M | 0.0 | 0.0 | 0.0 | 9.5 | 10.5 | 80.0 |
16 | M | 0.0 | 3.0 | 0.0 | 17.6 | 9.6 | 69.8 |
20 | M | 6.6 | 0.0 | 0.0 | 4.5 | 6.3 | 82.6 |
Mean ± SD | 3.6 ± 3.6 | 1.3 ± 1.3 | 0.0 ± 0.0 | 9.3 ± 5.2 | 12.2 ± 6.1 | 73.1 ± 8.9 | |
265-a | F | 0.0 | 0.0 | 0.0 | 0.0 | 67.3 | 32.7 |
285-a | F | 9.1 | 0.0 | 2.4 | 4.2 | 49.4 | 35.0 |
315-a | F | 6.8 | 0.0 | 0.0 | 7.3 | 50.1 | 35.8 |
325-a | F | 5.3 | 0.0 | 0.0 | 3.8 | 58.3 | 32.5 |
Mean ± SD | 5.3 ± 3.3 | 0.0 ± 0.0 | 0.6 ± 1.0 | 3.8 ± 2.6 | 56.3 ± 7.3 | 34.0 ± 1.4 |
For the calculations of mean and SD, the values shown as 0 were treated as equal to 0.
↵5-a Samples for rats 13, 26, 28, 31, and 32 were concentrated 2.5-fold using an ACN precipitation method.